Genetics Of Coronary Artery Disease
Genetics Of Coronary Artery Disease Discovery Biology And Clinical Translation Nature Reviews Genetics
Genetics of coronary artery disease. 24002717 Indexed for MEDLINE Publication Types. Abstract Coronary artery disease is the leading global cause of mortality. Genetics Key Factor In Coronary Heart Disease Not Lifestyle The fact that hereditary factors play a role in coronary heart disease has long been known but.
Possible risk factors include. Genetics of coronary artery disease. Knowledge of the new sequence variations in the genome that confer risk has the potential to illuminate new causal biologic pathways in humans and.
Some are caused by just one or a few genetic changes that have a very strong effect in causing disease. 2 3 Since 2007 genomewide association studies GWASs have identified a large number of common genetic variants associated with CAD. Long recognized to be heritable recent advances have started to unravel the genetic architecture of the disease.
Coronary artery disease is partly heritable. The tools applied include genome-wide association studies encompassing 200 000 individuals complemented by bioinformatic approaches including 1000 Genomes imputation expression quantitative. There is almost no data on the genetics of acute coronary syndromes so this review discusses primarily the 50 genetic risk variants associated with coronary artery disease that are of genome-wide significance in the discovery population and replicated in an independent population.
Common variant association studies have linked approximately 60 genetic loci to coronary risk. While enormous effort has been devoted to understanding the genetic basis of coronary artery disease and other common complex card. Cholesterol-enriched plaques in the hearts blood vessels combined with inflammation lead to the lesion expansion narrowing of blood vessels reduced blood flow and may subsequently cause lesion rupture and a heart attack.
Coronary heart disease affects approximately 154 million individuals in the US 1 and is one of the main causes of mortality and morbidity. 1 A familial component contributes to cardiovascular disease CVD susceptibility 2 but it was not until the emergence of genome-wide association studies GWAS that genetic loci have been identified that displayed consistent associations with coronary artery disease. Common variant association studies have confirmed 60 genetic loci with a robust association with coronary disease the majority of which are.
A possible cause might be from an injury to the inner layer of the artery where the disease begins to appear. This disease is an idiopathic disease which means there really is not a definite cause.
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Long recognized to be heritable recent advances have started to unravel the genetic architecture of the disease.
Coronary artery disease is partly heritable. 2 3 Since 2007 genomewide association studies GWASs have identified a large number of common genetic variants associated with CAD. Coronary artery disease represents the leading cause of death worldwide sparing no nation ethnicity or economic stratum. Cholesterol-enriched plaques in the hearts blood vessels combined with inflammation lead to the lesion expansion narrowing of blood vessels reduced blood flow and may subsequently cause lesion rupture and a heart attack. While enormous effort has been devoted to understanding the genetic basis of coronary artery disease and other common complex card. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Known as monogenic conditions they include uncommon disorders that mostly affect the hearts muscle such as hypertrophic cardiomyopathy or electrical system such. Genetic Determinants of Peripheral Artery Disease Derek Klarin Philip S. Unmitigated disease is associated with major functional decline.
All of these risk. Peripheral artery diseaseatherosclerosis of the abdominal aorta and lower extremity vascular bedis a complex disease with both environmental and genetic determinants. Known as monogenic conditions they include uncommon disorders that mostly affect the hearts muscle such as hypertrophic cardiomyopathy or electrical system such. 1 A familial component contributes to cardiovascular disease CVD susceptibility 2 but it was not until the emergence of genome-wide association studies GWAS that genetic loci have been identified that displayed consistent associations with coronary artery disease. This avenue however is not without challenges and limitations including the need for carefully designed and executed studies and the risk of false positive associations. Common variant association studies have linked approximately 60 genetic loci to coronary risk. 1 Studies consistently show that 50 of the phenotypic variance in CAD may be explained by genetics ie heritability.
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